etravirine will minimize the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.apalutamide will lower the extent or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine